A Two Year Open Label, Randomized, Parallel Group, Blinded Assessment Ophthalmologic Safety Study of Pramipexole IR Versus Ropinirole in Early Parkinson's Disease Patients
- NCT00144300
- PHASE4
- INTERVENTIONAL
Last updated: 2014-03-14
Purpose of Trial
To determine if there is any difference in the presence of retinal deterioration in PD patients treated with pramipexole IR versus ropinirole as monitored by comprehensive ophthalmologic assessments from baseline to the end of study at two years.
This study is for people with
Parkinson Disease
Interventions being studied
Mirapex
Requip
Inclusion criteria
Diagnosis and main criteria for inclusion. Patients must meet all of the following inclusion criteria to be eligible for enrollment into the study:
1. Patients with idiopathic Parkinson's disease of less than 7 years characterized as Stage I-III by the Modified Hoehn and Yahr Scale and with a maximum of 6 months cumulative lifetime exposure to levodopa and/or dopamine agonist. Patients on current dopamine agonist therapy would require 14-day washout.
2. Age at least 30 years.
3. Women of childbearing potential must have a negative serum beta-HCG pregnancy test at the Screen (Baseline) visit and the patient must use adequate contraceptive methods.
4. Evidence of a personally signed and dated informed consent document indicating that the patient (or a legally acceptable representative) has been informed of all pertinent aspects of the study.
5. Patients who are willing and able to comply with scheduled visits, treatment plan, and other study procedures.
Exclusion criteria
Main criteria for exclusion. The presence of any of the following would make a patient ineligible for enrollment into the study:
1. Previous history of allergic response or complications with any dopaminergic agonist drug
2. Atypical PD syndromes
3. History of stereotactic brain surgery
4. Positive hepatitis B (surface antigen) or hepatitis C (antibody)
5. Surgery within 180 days of randomization which would negatively impact participation
6. Folstein's Mini Mental State Examination (MMSE) score of 24 or less
7. History of active epilepsy (seizure) in the past 1 year
8. Third degree AV block or sick sinus syndrome
9. Congestive heart failure, Class III or IV
10. Unstable heart disease such as unstable angina, dysrhythmia, or myocardial infarction in prior 6 months
11. Symptomatic orthostatic hypotension
12. Clinically significant liver disease or renal disease
13. Malignant melanoma or history of previously treated malignant melanoma.
14. Prohibited medications taken (including any drug known to have potential retino-toxic effects taken in the prior 12 months; neuroleptics taken within prior 6 months, MAO inhibitors except rasagiline or selegiline taken within prior 3 months, beta-blockers taken to treat Parkinson's disease in the prior 30 days, and Coenzyme Q10 taken within 14 days)
15. Albinism/Albinoidism of any degree, type or syndrome
16. History of glaucoma with or without treatment
17. Inherited or acquired retinopathy such as age-related macular degeneration with visual loss
18. Sarcoidosis
19. Diabetes mellitus of any degree even if diet or insulin controlled
20. Best corrected visual acuity (BCVA) of less than 20/40 by ETDRS
21. Refractive error of greater than minus-6 diopters
22. Abnormal electroretinogram (ERG)
23. Unable to dilate pupils
24. History of severe eye trauma that might affect the outcome of the study
25. History of psychosis
26. Participation in other investigational drug studies or use of investigational drugs within prior 30 days
ELIGIBILITY
Gender: ALL
Age: 30+
Healthy Volunteers: No
21 Locations
Birmingham
248.538.00007 Boehringer Ingelheim Investigational Site
Alabama, United States
Little Rock
248.538.00008 Boehringer Ingelheim Investigational Site
Arkansas, United States
Fountain Valley
248.538.00021 Boehringer Ingelheim Investigational Site
California, United States
Los Angeles
248.538.00022 Boehringer Ingelheim Investigational Site
California, United States
New Haven
248.538.00001 Boehringer Ingelheim Investigational Site
Connecticut, United States
Miami
248.538.00002 Boehringer Ingelheim Investigational Site
Florida, United States
Tampa
248.538.00016 Boehringer Ingelheim Investigational Site
Florida, United States
Tampa
248.538.00023 Boehringer Ingelheim Investigational Site
Florida, United States
Atlanta
248.538.00013 Boehringer Ingelheim Investigational Site
Georgia, United States
Augusta
248.538.00009 Boehringer Ingelheim Investigational Site
Georgia, United States
Chicago
248.538.00011 Boehringer Ingelheim Investigational Site
Illinois, United States
Baltimore
248.538.00005 Boehringer Ingelheim Investigational Site
Maryland, United States
Southfield
248.538.00014 Boehringer Ingelheim Investigational Site
Michigan, United States
New York
248.538.00010 Boehringer Ingelheim Investigational Site
New York, United States
New York
248.538.00015 Boehringer Ingelheim Investigational Site
New York, United States
New York
248.538.00020 Boehringer Ingelheim Investigational Site
New York, United States
Charlotte
248.538.00012 Boehringer Ingelheim Investigational Site
North Carolina, United States
Philadelphia
248.538.00006 Boehringer Ingelheim Investigational Site
Pennsylvania, United States
Memphis
248.538.00004 Boehringer Ingelheim Investigational Site
Tennessee, United States
Houston
248.538.00003 Boehringer Ingelheim Investigational Site
Texas, United States
Morgantown
248.538.00017 Boehringer Ingelheim Investigational Site
West Virginia, United States
Primary Contact(s)
Boehringer Ingelheim
Data obtained from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Learn more at
ClinicalTrials.gov