Review the cytokine pathways involved in generalized pustular psoriasis (GPP) as compared to plaque psoriasis.
What you'll learn:
How uncontrolled activation of the IL-36 pathway by overexpression of agonists or loss-of-function mutation in the antagonist can drive pathogenic inflammatory pathways
The results of aberrant keratinocyte proliferation and differentiation
How neutrophil infiltration of the epidermis can lead to pustule formation
The outcome of increased proinflammatory cytokines and acute phase reactants
Access immunology disease state resources to support your knowledge and understanding of generalized pustular psoriasis (GPP).
Understand the burden of GPP and how to make a differential diagnosis