For US Healthcare Professionals Only

Review the cytokine pathways involved in generalized pustular psoriasis (GPP) as compared to plaque psoriasis.

What you'll learn:

  • How uncontrolled activation of the IL-36 pathway by overexpression of agonists or loss-of-function mutation in the antagonist can drive pathogenic inflammatory pathways
  • The results of aberrant keratinocyte proliferation and differentiation
  • How neutrophil infiltration of the epidermis can lead to pustule formation
  • The outcome of increased proinflammatory cytokines and acute phase reactants

Access immunology disease state resources to support your knowledge and understanding of generalized pustular psoriasis (GPP).  

Understand the burden of GPP and how to make a differential diagnosis
An Update on Generalized Pustular Psoriasis – Article An Update on Generalized Pustular Psoriasis – Article

An Update on Generalized Pustular Psoriasis – Article
Patient-Case-Studies Patient-Case-Studies

GPP Patient Case Studies – PDF
Interactive-Disease-Education-Quiz Interactive-Disease-Education-Quiz

Quiz: Rare Skin Disease Round-Up – PDF
IL-36 Pustular Psoriasis-Factsheet IL-36 Pustular Psoriasis-Factsheet

Immune System Activation in Pustular Psoriasis vs Plaque Psoriasis – Factsheet
Learn about the disease pathway for GPP and IL‑36
The-Role-of-IL-36-in-Inflammation The-Role-of-IL-36-in-Inflammation
Play Button.png

The Role of IL-36 in Inflammation – Video
Role-of-IL-36-video1 Role-of-IL-36-video1
play-button

The Role of IL-36 in Generalized Pustular Psoriasis (GPP) – Video
IL-36 IL-36

Role of IL-36 in Pustular Skin Disease – Factsheet
Learn about the disease pathway for GPP and IL‑36 Learn about the disease pathway for GPP and IL‑36

The IL-36 Pathway and Generalized Pustular Psoriasis (GPP) – Infographic